The question that has puzzled scientists for over 150 years is ‘what causes complex regional pain syndrome’? Unfortunately, there is no accepted cause for CRPS. However, it is generally thought that it results from a malfunction in the central or peripheral nervous system, whereby the nerves are effectively ‘rewired’ so that they send the wrong signals to the brain.
There is a growing belief that CRPS is an autoimmune disease. This belief has been strengthened by the encouraging initial results in the LIPS trial of immunoglobulin therapy for people suffering therapy resistant CRPS / RSD.